• Wang Y.-Z.1; Wang Z.-H.1; I. L. Eshel1; Sun B.; Liu D.; Gu Y.-C.; Milo, A.; Mei T.-S. Nickel/biimidazole-catalyzed electrochemical enantioselective reductive cross-coupling of aryl aziridines with aryl iodides. Nat. Comms. 2023.
    ( 1 contributed equally)
  • Alassad, Z.1; Nandi, A.1; Kozuch, S.; Milo, A. Reactivity and Enantioselectivity in NHC Organocatalysis Provide Evidence for the Complex Role of Modifications at the Secondary Sphere. J. Am. Chem. Soc. 2023, 14589-98.
    ( 1 contributed equally)
  • Alassad, Z.1; AboRaed, A.1Shema Mizrachi, M.; Pérez Temprano, M. H.; Milo, A. Metal-Free Multicomponent Strategy for Amidine Synthesis. J. Am. Chem. Soc. 2022, 14420672-20679.
    ( 1 contributed equally)
  • Domb, I. 1Lustosa, D. M. 1Milo, A. Secondary-sphere modification in proline catalysis: Old friend, new connection. Chem. Commun. 2022, 58, 1950-1953.
    1 contributed equally, advance article Emerging Investigators collection)
  • Nandi, A.; Alassad, Z.; Milo A.; Kozuch, S. Quantum tunneling on carbene organocatalysis: Breslow intermediate formation via water-bridges. ACS Catal. 202111, 14836–14841.
  • Gadekar S. C. 1Dhayalan V. 1Zak, I. L.; Nandi, A.; Shema Mizrachi, M.; Kozuch, S.; Milo, A. Rerouting the Organocatalytic Benzoin Reaction toward Aldehyde Deuteration. ACS Catal. 202111, 14561-14569.
    ( 1 contributed equally)
  • Zak, I. L. 1; Gadekar, S. C. 1; Milo, A. Designing the Secondary Coordination Sphere in Small-Molecule Catalysis. Synlett 2021, 32, 329-336.
    ( 1 contributed equally, Invited synpacts article)
  • Abo Raed, A. 1; Dhayalan, V. 1; Barkai, S.; Milo, A. N-Heterocyclic Carbene Triazolium Salts Containing Brominated Aromatic Motifs: Features and Synthetic Protocol. CHIMIA 2020, 74, 878-882.
    ( 1 contributed equally, Invited, Published as part of the special issue on Innovative Tools in Organic / Organometallic Chemistry)
  • Dhayalan, V. 1; Gadekar, S. C. 1; Alassad, Z. 1; Milo, A. Unravelling mechanistic features of organocatalysis with in situ modifications at the secondary sphere. Nat. Chem. 2019, 11, 543–551.
    ( 1 contributed equally)

Editors’ Choice: Yeston, J. Outside help for a carbene catalyst. Science 2019364, 967-968.

Alassad, Z.  Modifications of organocatalysts in the reaction vessel to control enantioselectivity. Nature community-behind the paper.

  • Dhayalan, V.; Mal, K.; Milo, A. Practical Synthesis of Chiral N-Heterocyclic Carbene Triazolium Salts Containing a Hydroxy Functional Handle. Synthesis 201951, 2845-2864.
    (Invited, Published as part of the Bürgenstock Special Section 2018 Future Stars in Organic Chemistry)

  • Milo, A.; Pérez Temprano, M. H. Highlights from the 53rd EUCHEM conference on stereochemistry, Bürgenstock, Switzerland, May 2018. Chem. Commun. 2018, 54, 10014

before BGU

Spotlights on Recent JACS Publications: Su, X. Steric effects clarified for Hammett analysis. J. Am. Chem. Soc. 2016, 138, 14159–14159.

  • NiemeyerZ. L.MiloA.HickeyD. P.SigmanM. S. Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes. Nat. Chem.  2016, 8, 610–617.
  • Neel, A. J. 1; Milo, A. 1; Sigman, M. S.; Toste, F. D. Enantiodivergent fluorination of allylic alcohols: dataset design reveals structural interplay between achiral directing group and chiral anion. J. Am. Chem. Soc. 2016, 138, 3863–3875.
    ( 1 contributed equally)

Highlighted: List, B.; Mandrelli F. Data Set Design for the Asymmetric Fluorination of Allylic Alcohols. Synfacts 2016, 12, 0637.

Spotlights on Recent JACS Publications: Su, X. Enantiomeric Excess Helps Identify Origin of Enantioselectivity. J.  Am. Chem. Soc. 2016, 138, 3933–3934.

  • Milo, A. 1; Neel, A. J. 1; Toste, F. D.; Sigman, M. S. A data-intensive approach to mechanistic elucidation applied to chiral anion catalysis. Science 2015, 347, 737-743.
    ( 1 contributed equally)

Perspective: Lu, T.; Wheeler, S. E. Harnessing weak interactions for enantioselective catalysis. Science 2015, 347, 719-720.

Research highlight: Hennessy, J. Asymmetric synthesis: Catalysis exposed. Nat. Chem. 2015, 7, 270-270.

Highlighted: University of Utah press release, C&E News,, ScienceDaily, Forbes.

  • Milo, A.; Bess, E. N.; Sigman, M. S. Interrogating selectivity in catalysis using molecular vibrations. Nature 2014, 507, 210-214.

Selected by Chemicals Technology as one of the biggest Chemicals Technology stories of 2014.

Highlighted: University of Utah press release, C&E News,, ScienceDaily.

  • Milo, A.; Neumann, R. Achiral ruthenium catalyst encapsulated in titanium phosphonate homochiral peptide-based solids for enantioselective hydrogenation of ketones to secondary alcohols. ACS Catal. 2012, 2, 2531-2536.
  • Milo, A.; Neumann, R. An achiral manganese salen catalyst encapsulated in a peptidic phosphonate homochiral solid for the enantioselective formation of diols by consecutive epoxidation and hydration reactions. Chem. Commun. 2011, 47, 2535-2537.
  • Milo, A.; Neumann, R. A tripodal peptidic titanium phosphonate as a homochiral porous solid medium for the heterogeneous enantioselective hydration of epoxides. Adv. Synth. Catal. 2010, 352, 2159-2165.